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Unlike small drug molecules, peptides can be targeted specifically to their biological targets. But delivering therapeutic peptides via intravenous infusion has been challenging. Now scientists in ACS Central Science have embedded a peptide from European honey bee venom—mellittin—into the membrane of red blood cells (RBCs). When illuminated by light, the engineered RBCs release melittin, which causes them to rupture, and the cell-targeting peptide is released within the tissue.
This peptide is free of whey, lactose, soy, casein, nuts, and corn and flows smoothly through enteral feeding pumps. It was synthesized by standard solid-phase peptide synthesis at Zhejiang ONTORES Biotechnologies Co. Ltd (Hangzhou, China) and characterized by electrospray ionization mass spectrometry. Its purity was greater than 92%, and the quality report is shown in Supplementary 1.